Project Description

This project focuses on the whole genome sequencing, assembly, and functional annotation of rare Actinomycetota strains collected from diverse Indonesian environments. Actinomycetota are renowned for their exceptional capacity to produce bioactive secondary metabolites, including antibiotics, anticancer compounds, and industrially relevant enzymes—yet many rare lineages remain genomically unexplored.

Through the generation of high-quality, near-complete genome assemblies, this project aims to unlock the biosynthetic potential of underrepresented Actinomycetota and establish a foundational genomic resource for natural product discovery, comparative genomics, and synthetic biology applications.

Project Goals

The main objectives of this project are to:

• Generate high-contiguity whole-genome assemblies of rare Actinomycetota strains
• Perform comprehensive genome annotation, including biosynthetic gene cluster (BGC) detection
• Enable genome-guided bioprospecting of secondary metabolites
• Build a curated genomic dataset to support downstream comparative and functional analyses
• Strengthen national capacity in long-read microbial genomics

Acknowledgements

This project is funded by the Riset Inovasi Indonesia Maju (RIIM) – Ekspedisi Grant, in collaboration with Universitas Teknologi Sumbawa (UTS), Synbio.id, and Integrated Genome Factory.